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Methods for the generation and evaluation of such variant TetR and, therefore, revTetR proteins and evaluating the affinity with which they bind to naturally-occurring and variant tet operator sequences are well known in the art.

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In this embodiment, rather than combining an entire DNA-binding domain from a non-revTetR DNA binding protein with a tetracycline binding domain derived from a revTetR protein, only those residues or segments involved in DNA sequence recognition are used to construct the chimeric proteins.

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